Never is the answer to your question including the 21mm.
I sailed on U.S. flag ships as a merchant marine engineer , deep sea, for 30 years. The ships were mostly 4000 HP per cyl slow speed diesels. Since I have worked on machinery for years that had metric fittings I would take away all the sockets from the workbench that were never used. I would leave available 4,6,8,10,12,13,14,17,19,22,24,27,30,32,36,41,46,55,60,65,85 and some larger size special sockets and slugging wrenches.
A freind of mine, a 40 year VW and Porsche mechanic told me he uses them all. Personally I have never used sizes like 11,15,16,18,20,21,23,25,26. These wierdo sizes are possibly included because some foreign diesels like Burmiester and Wain were all metric except for WHITWORTH fuel system thread bolts, go figure. I think that some Whitworth bolts had odd hex size on the bolts or nuts.
American socket sets used to include stuff like 25/32, and 31/32 to fit occasional metric hex on American cars or engines or Whitworth.
Don't even get me started on what I think about Whitworth pipe threads.