Tiles are EXTREMELY strong in compression, they're just really brittle.
If you...
used good modified thinset.
used very hard tiles (prob. ceramic or porcelain), NOT travertine or any soft stone
had a good solid substrate (like a structurally sound garage floor)
were REALLY sure you had no voids under the tile (check your coverage periodically as you tile)
I think I would be fine. I hear everyone else's concerns about possible breakage, and yeah, it can happen, but have any of you ever TRIED to break a ceramic or porcelain tile that has been set in place in modified thinset? I had to when we did our kitchen b/c we set one little one in the doorway just a hair high.
My first attempt was a few swings of the 1 LB claw hammer swinging as hard as I could down onto the edge of the tile. It didn't even chip.
I eventually graduated to a 4LB hammer and a masonry chiesel, and even then, it took some considerable work to crack it, let alone break it to the point any piece could be removed.
If you do tile, remember wider grout lines=more friction for your feet, less chance of slipping. Using smaller tiles also means there is more grout surface area, so more traction, but I'm not suggesting you tile your garage floor w/ 0.75" mosiacs
