Johnnie, I've done a few wheels in my time, and the last (for my VW Westfalia), I stripped myself, and had powder coated. That is the best finish for wheels IMHO.
That said, I've also clear coated autocross rims which were bare aluminum, and they held up surprisingly well. Pretty much sanded them, then straight on with clear.
If you're set on painting, I'd start with cleaning the wheels very well with TSP and water, then coating soon after with epoxy (2 part) primer. If you're looking for a solid color, a two part urethane in silver metallic will likely look good. You can also base/clear, however you'll spend some dollars for good paint. The guys I purchase from locally sell BASF, so that's what I use.
You're biggest challenge will be paint runs, vs dry spray. Use really good lights, and get just enough paint on there to wet the surface. Any more and you'll run. Be patient, and follow the flash time recommendations on the product. For wheels, you'll want to keep the paint layers as thin as possible.
You can set up a plastic enclosure with a fan pushing air in via furnace filters, and filters again on the exhaust side of your booth to catch over spray. I've done this numerous times with no issues as the fan is pushing in fresh air. Winter spraying can be hard as you'll want the garage door open, but heated air coming in. Regardless, you'll need to invest in a good mask with appropriate cartridges for what you're doing.
Painting is a PITA, as well as a lot of work..but it can be quite rewarding too. Page 21 and Page 22 of my thread cover some paint work, and the plastic "booth" I made as well:
https://www.garagejournal.com/forum/showthread.php?t=263351&page=21