Very deep subject...so much that,I'd do it a misjustice to even try a synopsis.
Start with what you're trying to "clean-up"....and you can then start a plan.
Then I'd strongly suggest learning some sheet metal skills...along with an investment in tools/equip in that arena.Several years ago when I needed to expand our shops DC....the only place anyone would even give me the time of day,so to speak.....was here on GJ.The question was how to make a sheetmetal wye.....can't remember the guy(apologies),but it was like a litebulb coming on!And practice this craft almost daily since.
So,thats a start.....accurately describing what particulates,and then learning to roll you own sheet metal.Plastic and wood have EXTREMELY limited use in building proffesional units.
I call them "dump boxes"....don't know where it came from?Maybe its a real term,might be my imagination?But in any case......imagine a dishwasher sized box sitting on the floor.Near the top of it,a 4" duct comes in one side......opposite side theres another 4" duct.The airflow is obviously traveling through the duct....what do you think happens to the duct or line pressure when all of a sudden it hits that big open space?
Start study'n commercial designs on E-Bay......look for the dump bx style I halfass described above.
Aerodyne has some interesting engineering you can study as well.....looking at their horizantal "cyclone'ish".....very Nascar air scrubbers.Its a tube inside of a tube(albiet 10' in diameter)....with opposing air streams fighting it out....particulate is sort of magically "expressed" right the f**k out of the airstream.