As others have said, it really depends on how you are going to use the space. I went back and forth for a while on which side to put the doors in. Most of my shop stuff is auto related, and I’m putting in a lift, so that went factored into my decision. I ultimately decided that it would work better for me to have a “lift bay” that I keep open most of the time (pull in, fix, pull out), and still have two bays for parking or longer term projects (my son’s 64 pickup is going out there). Had I gone 2 wide, I could have also gone 2 deep, but I felt like it wouldn’t be as flexible a space for my intended use. One of my father-in-law’s shops is 30 x 40 with a single 12 ft door in each gable end, and it works really well for its intended use. More woodworking type stuff goes on in there, with pretty much nothing car related. That’s what his big (65x60) shop is for. It is a pretty personal decision, and there are a few right answers, but really no wrong answers... as long as it works for you.