I just finished half my basement that has a floor drain with Epoxy-Coat and there was absolutely no issue with it running or thickening on the lower portion of the floor. I'm still trying to decide if I should paint the metal drain cover or Epoxy-Coat it to match with a bit I have left.
Oh, and I tested it accidentally by spilling a decent amount of water and it really makes water flow to the drain very very quickly.