Not sure I would recommend that you put them in the concrete. I ran my supply for a future snow melt system under my slab and it’s insulation. I ran 1” pex in armaflex and wrapped it in heavy plastic. This will allow me to run hotter temps to the manifold and use a mixing valve to get the desired temp. Will your heating plant be able to deliver exactly the temp fluid you want to run in your floor? What size tubing did you intend to put in the slab to feed the manifold, would you be concerned about crossing over the pex loops? If you ran the supply and return lines under your slab & insulation you can run in a straight line from heating plant to manifold location.