If you are only using it on weekends, I would install a hanging furnace and call it done. Nothing uses less energy then having the system completely off. If you insulate the building well, slab included, it will heat up quite quickly as needed and ultimately use far less energy than leaving it heated partially and then having a boiler run full tilt for 4-6 hours to heat it up. I did a radiant/insulated over-pour combined with air handlers in a 9000 square foot commercial building (very well insulated) and honestly regretted doing the radiant. The air handlers were far quicker and more efficient to warm the space when needed. I had nine ecobee stats in the building so tracked run times etc. between radiant and the air handlers over a few years. Insulate your slab yes, and run tubing if you want. It may make sense in the near future to use an air source heat pump, towards electrification and ASHP..but it makes no sense for your use case as described IMO.
The only place radiant actually made sense in that building was the loading bay, which was left at about 8-10 C at all times and had a 10'x12' overhead door. I ran lots of tests given the rather unique situation of having both radiant and air handlers to manage the main floor heating/cooling. The Ecobee stats make data analysis pretty easy via web logging and reporting using beestat.io (highly recommended!). The slab was fairly quick to react as we insulated over an existing slab, and added just 2" of concrete for the radiant. It was expensive and ultimately we should have just stuck with the air handlers as they needed to be there for fresh air and summer AC anyway. As you're building a pretty massive garage, for a cottage, my guess though is that efficiency may not be your first concern here...
I leave my detached shop completely unheated except when needed. Outside temps here in winter can hit -35 C, but the shop never dips below -10. It was built sometime in the 70s and is structurally 100%.