How large is your shop?
For a one a two or three car garage I don't see a reason for much duct. My furnace sits about 1/3rd the way and a 40 foot wall. The duct consists of a 24" run, the splits into two ducts, but they are short. One is straight, the other has a 45 degree elbow. both have vanes at the openings to deflect the air down. The whole duct run is 3-4 feet. I also have a ceiling fan and the shop is comfortable.
If you insist on running duct across the shop, size your duct for the CFM at the air handler, run it about half way, install half of the registers, then resize the duct for 1/2 the CFM and mount the other half of the registers.
Your AHU should have fan speed information available. You mentioned a 5 ton AHU, but i would assume you will run the blower motor on 3rd speed. 1600 CFM for 4 ton requires a 12"x20" duct, or something similar, 16" square would work too. The other half of the run requires a 12" square duct.