Few quick observations, some already mentioned by other GJer's:
a) Pocket door to bathroom
b) Re-design bathroom so no water lines on exterior walls. Same design concept overall to NOT have any water lines in exterior walls (prevent freezing and makes maintenance easier).
c) Windows not centered on either side (looks bad, but may be necessary). Maybe consider 2 windows. See last item as ought to make one a sliding door with deck (likely on left side of drawing near top of stairs).
Don't make windows too small as the cross ventilation up there will be optimal.
d) +1 that you'll want deeper garage than just 24 ft (as much as you can !!)
e) I'd slide the man door on left side over a bit to right so there is space for light switches and walking room on the left side
f) 8 ft tall garage doors
g) Garage door just to right of man door might be small one as you'll use it most (maybe 9' x 8') and prevent loss of heat/cool each time garage door is opened. Big garage door at far right of 18' x 8' if room, or 16' x 8' at minimum.
h) Design space to optimize ductwork for heat/cool - - don't skimp on ductwork as it's lifeblood of keeping space comfortable. With tall enough ceiling in garage, you could go exposed ductwork for "industrial look" but I'd still recommend good insulation in garage ceiling for sound deadening to keep living space quiet. You'll need 2 systems so fumes from garage aren't shared with upstairs living space (one upstairs central heat/air system, and seperate lesser system for garage which might be hanging heater and mini split A/C).
i) Where utilities attach to exterior wall (ie electric meter / natural gas line), make that permanent material like brick, as nothing worse than residing 15 yrs later when cheap masonite siding falls apart. Thus, I'd recommend maybe full brick on front, and several feet brick on exterior sides.
j) Nice feature to assist in building (ie get stuff upstairs), is build a deck with sliding door on one end of the upstairs living space. Design REMOVABLE RAIL so that big furniture, 12 ft sheetrock, etc. can have straight shot into the upstairs. Deck could just be big enough for couple chairs to drink coffee in morning and enjoy the view.