I don't wrench professionally any more, but when I did it was on motorcycles. Owners get real particular about wrench marks on chrome plated fastener. For that it was six point all the way, and no flank drive.
Funny you mention that.
I'm no pro, but I bought a set of aluminum 6pt wrenches specifically for this purpose on my Harley. I want my chrome shiny!!!
For the OP. I've found that 12pt serves my needs fine 99% of the time.
I keep a few 6pt wrenches around for specific applications, like strut shafts and other things that are sensitive to being rounded. Not necessarily brake bleeders. Those get a 6pt line wrench, not a regular boxed end wrench.
However sockets are ALWAYS 6pt for me. Excepting the rare case where it's a 12pt nut/bolt.

That's allowed, right?