As a long time mechanic, 12 point is the first choice. The 12 points are faster and easier to use. They are much better when using a tool like a breaker bar, T handle, or non ratcheting torque wrench, etc. If you have a flank drive socket like a Snap-On, the 12 point will work nearly as well as a 6 point and is all that is needed 99.99% of the time. I do not even own many 6 point sockets. If you were to measure the torque it takes to round off a fastener, the 6 point will give you little more than a 12. The exception where 6 points have their worth is in places like exhaust systems or industrial highly corrosive environments or applications where the fasteners get beat up. And 6 point box end wrenches are totally worthless.
I normally use 1/4" drive up to half inch sockets and would not want to have to use 3/8" to turn those sizes. Likewise with 3/8" drive up to 3/4" sockets. If you use them every day on the job, speed and ease of handling is important and the smaller sized drive tools and 12 point sockets win out.
.