The comment about, "man that two-drawer sure-got heavy!" I find is an issue. I've picked-up a few of the roughly 18"-19" Craftsman toolboxes, w/the removable tray in the top. I also have a larger old Craftsman grey 2-drawer which I use for in-the-house tools, so I don't have to go to the garage. I have it on a furniture dolly, one of those shorter ones which can also be a 4-wheeled cart. It fits in a closet.
I also have a red Craftsman 2-drawer for pliers and screwdrivers (mostly duplicates), and miscellaneous small tools, and it's also heavy when full, though I don't have to move it. I bought it new probably 30 years ago.
I've thought of using some nylon strap, like seatbelt material, to make an over-the-shoulder strap to make it easier to carry a fully-laden Craftsman top-handle toolbox. I don't need-to carry one very-often, but when you did, it would be much-easier.You could through-bolt or pop-rivet a pair of brackets onto the ends of the toolbox for the strapping, or you could attach the webbing directly to the box using the same method. I was thinking of a removable strap, though.
Sears sells a blow-molded grey toolbox, long, low, and pretty-wide, for a 'behind the p-u truck seat' (or under it) toolbox. I used one of those for many years, though I rarely used the top-of-the-toolbox handle, I'd carry it at the ends, because full of tools, I didn't trust the plastic handle to safely-carry the load.