They both have their place. We've got everything covered in this discussion at work. I use an a-symmetical 9K rotary 2-post for 90% of what I do at work... Which is pretty much any repair on our dealerships late-model unibody sedans.
I've had a powerstroke excursion on my rack, you just load it more like a symmetrical lift, with the vehicle as far forward as the front legs allow. That said, I wouldn't want to do much more that brake/suspension/oil changes with that setup, as the vehicle rocked a bit if you hung on the front bumper and pushed. On a symmetrical lift big vehicles are much more stable. If you plan to work on a lot of fullsize trucks, get a symmetrical.
We use the drive-on racks (an in-ground and a 4-post) for alignments and for something else you can't do on a 2-post lift: Finding suspension noises. I drove a customers car the other day that had a freaky rattle over large bumps from the R/F tire. I couldn't disagnose on my 2-post - checked all suspension parts, etc and EVERYTHING was tight.
So I put it on the 4-post and you could recrate the sound by smacking the sidewall with a dead-blow mallet. I stood on the brakes with the car 4 feet in the air while another guy did the swinging. The noise went away when you applied the brakes. Came back when you released them. Turned out whatever shop had just done a brake job on it hadn't properly installed the inboard brake pad into the caliper, and it rattled over bumps...
Try diagnosing that without being able to peek under the car with the vehicles weight on the suspension.
With all that said, I use each type of lift regularly, and I plan on installing a lift at home eventually. And it'll be a symmetrical 2-post, since I do a lot of work on fullsize trucks. If I didn't, it'd be an a-symmetrical.
With a lightweight vehicle like the Ranger and the Mustang you mentioned, which weigh around a third of the typical 9K capacity, I'll spot it more like an a-symmetrical - shift the car back enough to easily open & close the doors. You'll still be way below the weight limit on each arm of the lift. The only issue you run into is wether or not the arms will collapse/extend enough to reach the pickup points.
BTW, on a unibody vehicle like the mustang, if I'm just doing brake work, I'll set the feet under the pinch-weld as close to the front & rear tires as possible. Makes for a quick lift, and works very well. If you're going to be hanging from the vehicle or pullling trannies, rack it further in on both sides. That way, even if disaster strikes and the vehicle shifts over 6 inches, the foot slides off the sub-frame and might crush the floorboard or something, but it can't fall off the rack to the ground.
With regards to the '40... I installed a new brake switch my brothers restored 49 Chevy this weekend. Fullsize trucks and old cars with big ladder frames are the easiest to rack. You set the feet so they catch the frame as far forward & back as you can get. That's about it. Very stable.
Since you mentioned fullsize trucks, I'd be looking at a 2-post symmetrical if I were in your place. You might have to **** in your gut since the door will only open 16" or so on an F-250 parked waaaay forward for porper balance, but the rest of the time, it's a non-issue, and I wouldn't want to do much work on a F250 balanced on an a-symmetrical.