My approach to an interview is one of total honesty, and knowing how to "pass the ball" back and forth. I always like to ask the interviewer lots of specific questions about their business, even if my questions seem bizarre or insignificant. "How did you find this place? What's your favorite tool? How do you approach this?"
When I am unfamiliar with a role or responsibility, or lack a skill, I am honest and indicate a willingness to learn. My resume is also neatly laid out, with good descriptions of my experience and a unique layout that fits my personal aesthetic (Color, personal logo or graphic, nice paper, etc).
With this approach, I have worked in several different fields; including woodworking, masonry, art conservation, antique restoration, real estate development, and presently architectural and interior design. My formal education was in traditional silversmithing and metal sculpture. I feel fortunate to have relative success with my job search, but I don't think anything I have done is particularly extraordinary. It's all about relating to someone and showing a vested interest.
Good luck with your job search!