If you are powering a shop subpanel from house main panel thru proper 2 pole breaker located in house main, and if you use properly sized(for alum) conductors, and if you terminate those conductors properly, and if the main house panel breakers and subpanel are designed for use with alum feeds, then go for it.....
Read up on how to properly feed a subpanel. Pay close attention to how bares and neutrals must be configured/bonded in the subpanel and house main. You will need to pull 4 whatever size alum or copper conductors from house panel to subpanel...2 will be insulated 120V hots, one will be insulated neutral, the 4th will be bare.
All must be sized accordingly considering alum or copper and length of run and amp capacity, and all connections must be made properly considering the type connection, the materials used for conductors and lugs, and the expected amp load.