I just did this in my house last week over Christmas break. I did 15 inches over 1417sqft, so roughly 2500lbs (125 bags) of the stuff (cellulose). It took almost exactly 10 hours to blow that much in, so figure on about 10-12 bags an hour if you've never done it before. Also as sands35 mentioned, definitely check any recessed lights, and fix any air penetrations from the floor below.
You will need a respirator, not a dust mask or your t-shirt over your face, but the kind with the pink filters on the sides. I completely clogged mine up by the time it was over. Cellulose is VERY dusty, so use some plastic sheeting, or something similar, to cover whatever access hole you are using. As several people has said, it's a minimum two person job (3 is better).
Some other useful tips I learned:
1. if the hose isn't long enough (online it says you get 100ft, but all three HD's I went to only gave a single 50ft) you can stick the end of a normal shopvac hose into the end of the hose it comes with, and it works great (I added another 25ft shopvac hose to mine). And the strait sections of shopvac tubing work great to get out to the soffits.
2. you can tie a long stick to the hose to help reach the soffits (although I found my shopvac tubing worked better)
3. you need lots of light to see what you are doing. This stuff is dusty, so it can be hard to see sometimes.
4. a Tyvek suite is highly recommended.
5. use something to mark how high you want the insulation. I used 2"x15" pieces of cardboard stapled to my roof trusses, so I just had to fill until I didn't see the cardboard any more.