I upgraded my parents house from a 60 amp fuse panel with two pullouts and six screw in fuses, and installed a 30 place GE 200 amp main breaker panel with new service entrance cable, meter socket and disconnect and all. I tried to avoid the splices in the panel, and generally ran new NM cable back to the first box/junction/device in the circuit. I put a couple of 4x4 boxes in the attic above the panel and made some of the splices there, with new NM down the wall to the panel.
Charles