And, like Bill said, I’d certainly look closely at the nut before I went to the trouble and expense of getting a new main screw made. And you’d still need a new handle too right?
I can’t think of an instance where making a new main screw AND a new nut would make economic sense. If you’re just looking for a project and will be repaid by the satisfaction of a job well done, then go for it. If you’re just looking for a useable vise, I would just look for a serviceable replacement.
Put an ad in the GJ wanted section. Lots of us have extra vises for sale at reasonable prices. I do.