I'll throw my hat in the ring. I worked for a couple of contractors in college and worked with my grandad on building projects so i've got several houses under my belt, and last built the house we are in now. It was our dream home.
I'm a design / mechanical engineer, and VERY DIY oriented. Basically nothing i don't like doing working with my hands, from welding, metalwork, woodworking, crafting, wiring, etc. We wanted to build a replica Victorian home, so i bought a few of the home design books on the market, we looked through them until we found one we liked, but ordered the CAD plans from the company. I used Autocad to make a few changes, including widening the house 4' and adding a hallway where there was none. Since i had access to a wide format plotter, i printed all copies of the plans after that.
I acted as GC, and hired a builder to erect the framing and roofing. I hired an HVAC guy (more on that later), and subbed out drywall. I handled all wiring, plumbing, finishing, siding. So subbed trades were excavation, sewer, foundation, framing, roofing, insulation, and HVAC. Getting financing as an owner/builder is tough. We worked through a local lumberyard's owner / builder program. They shepherd you and pay bills on your behalf while they hold the note. When done, they flip to a mortgage company.
Consider this so you can focus on your preferred trades. I did all this while working 50+ hrs day job. We broke ground in May 07, closed in May 09. We built right during the housing crash. There were warning signs as we signed the note, lender said don't worry about it, then it crashed. We closed upside down and i'm certain there was a payoff in there somewhere to get it off the books of the lumber yard. The original note was for $353K. The final house size is ~3000ft with attached 2 car garage with some premium features, but not as many as we should have had. Controlling costs was tough. I got some great deals on distressed items on ebay, ended up with premium Thermador appliances, a fancy lighting controller and a hybrid geothermal/boiler/ radiant floor hvac. My original contractor didn't know the ins/outs of hydronics and delivered a system that didn't work well. We closed with a barely functional system, and i had to buy books and learn hydronics and controls and rip it all out a year later and redo everything myself, which cost me an entire summer of spare time, and over 5G worth of fresh copper lines. After that refit, not counting my time and all the additional costs incurred, we're sitting right around $130/ft.
After about 10 years being upside down, the house has finally appraised high enough to get into a refi and i dropped my monthly cost by 1/2. I also had to carry a 2nd mortgage for a lot of that time. NO FUN.
When we started the process, i had banked on a lot of help from friends and neighbors and what i got was one neighbor helping me a little, mom and dad a little and a lot of bailing friends. So consider your actual needs doing this.
It is one of the most stressful things you can do in life, and if your marriage isn't VERY strong, don't attempt it.
Would i do it again, i would say maybe, but would significantly change what i do, and my wife would say NEVER.
Hope this helps.