A door opening is generally framed with a header (the heavy beam above the opening) no longer than necessary. So, if you have 10 or 12 foot wide doors, you probably have two headers about 12 or 14 feet long with their center ends supported by the center column.
As zeke said, most single, double car, doors are 16 feet left to right. And will need at least an 18 foot header spanning the entire opening. You will end up with one 16 foot wide opening.
Chris705 is worried about a load bearing wall and the stronger framing needed if it is a wall supporting the roof. Gabel end walls are not load bearing, so the temp bracing used while doing the work is not as critical.
Can it be done? If you stay with the normal 16 foot wide door, yes, any good framing carpenter can handle it. Anything wider than that will be much more of a project.