I'm about ready to insulate the ceiling in the garage but I need to put ductwork in for the 20x50 upstairs. Can I just put a 6" duct in each room with a damper or is it more complex than that? I framed out for 1-10x12 bedroom, 2-10x15 bedrooms, and a 5x10 bathroom. The living room/kitchen/dining room is all open.
It's much more complex than that. I'm not an expert in this field but I muddled through it recently for my workshop.
The best way is to first size the HVAC system by calculating the heat gain/loss. Then choose the equipment. The AC and furnace will have specs for air flow. Size the ducts to meet the total airflow needs and the airflow for each room or area.
It's pretty easy to estimate air flow needs for AC from the specs on the equipment. For example, the manual for the equipment I've picked out said optimal airflow for the AC was 400 CFM per ton (12,000 Btus) of cooling. This becomes the minimum airflow to be provided by the system. Divide this airflow into each area by using the ratio of the individual heat gain for the area to the total heat gain. Size ducts accordingly. See chart below.
Estimating furnace requirements is more complicated because you need to know which temperature rise will provide the optimum heating Btus. One furnace I looked at had a CFM range of 550 to 1150 depending on which fan speed provides the correct temperature rise.
I ran into a local engineer who gave me some rule of thumb advice for the workshop that I think will turn out to be good since it exactly matches how my house duct work is sized and that system works well.
He said to start by calculating the airflow for the AC system using 400 to 450 CFM per ton.
Then for the furnace, use 1 CFM per sq. ft. of area.
Increase each result by 10% if using flex duct since it is more restrictive, and increase the result by another 10% for 10' ceilings.
Then, use the higher of the AC or furnace airflow calculation to size the ducts.
He gave me some airflow numbers for round ducts.
CFM provided by round metal ducts:
6" = 100 CFM
7" = 145 CFM
8" = 210 CFM
9" = 290 CFM
10" = 390 CFM
12" = 620 CFM
This rule of thumb might not work in your area if your climate is much different but it might get you in the ball park.
Hope this helps.
DC