Symmetry has a lot to do with the choices, but do you need so many doors. Without seeing you plan view concept, it is hard to visualize what you are thinking, but why so much door area? I am completing a 30 x 40 and have two doors. One on each end, a 8'W x 7'H on one end that has no access to a street or alley, and the other end has a 12'W x 8'. I don't plan any motor homes or battleships to be driven in the shop at this point. Two bad things about too much door are that it reduces the wall space to put things against and the other is the structure itself. If the opening is too close to the corner of the building a "Strong Wall" is needed when there is less than 4' from the opening to the corner. Again, I don't have any idea if you are building a steel building or from stick. The last comment about the wood structure. Also, doors that size are going to get pricey. Shows us a plan view hand drafted if necessary.
Good Luck in your build.