I believe 3/8 is the common size for cooler lines, although there are 4 Jiffy Tite sizes commonly available.
Picks easily remove them once you find the end, however reinstalling isn't always the easiest to get the wire section back in. Plus it can be dropped into the abyss. If the connection is being replaced, like a new radiator, I typically use a pick. If the clip falls into a void in the subframe boohoo. If I'm reusing I will resort to a pick last, a pair of Knipex Cobras can rotate the tool in a crusty connection. Typically that will fail only on aluminum connections which will fill up with corrosion.