I burn a propane construction heater in my 30 x 40. I was worried about CO so
I got a CO detector. Last Saturday, my garage started out at 22° and I burned my heater On "high" - 80k setting for five hours and brought the temp up to 57°.
I checked the CO detector and the display never moved off "0".
I use 30# tanks and normally, on the low setting, 30k, I can get 20 hours (about 5 average days) of burn time per tank. I go thru 3 or 4 tanks per season. I have one on the heater and a full spare.
If I start my snow blower and run it for a few minutes, the CO detector definitely goes up!