I would suggest a process starting with a duct pressure test. Find out what you have now and what its condition is. In my home the duct system was so poor taht the very good equipment which supplied it couldn't operate properly. I tore it all out, and made a couple dump runs with it. I dined two closets and storage under the stairs. I don't think my situation is uncommon. It is very difficult to repair and properly seal old ductwork. If you do it, you end up with dirty old sealed ductwork that you are then going to throw modern equipment at.
I don't care for the ceiling cassettes. They work fine, but are difficult to clean and drain lines have to be spot on in them. The high wall units are best in operation and easiest to service. Frequently I have heard people say, "I can't have that on my wall." Then once they are in place they cannot believe how they got along without them and how comfortable they are an how efficiently they operate.