The answer is yes.
5 critical things in my opinion.
1. Must do engineering calculations to size the I-beam necessary for your weight and span. If unsure, copy the sizes from the catalog of people who manufacture these things. Wallace is one such company.
2. Must have mastered the critical skill of full-penetration welding. Back bevel everything and run wide open on a 250A mig if you are not stick-welding, 7018 preferred.
3. Load transfer from the beam to the columns is critical. Cannot be just a perimeter weld on a tube. Consider the lever arm on that joint should the gantry start to flex out of square and parallel as its loaded up.
4. Casters must be sized for load in #1 above. Consider the case where you trolley the load all the way to one end of the beam.
5. Strongly urge you to consider where/how it will be stored. As, 99.99% of the time after the first job that you build it for, it will sit around. I built this one to straddle this bench by 1" either side. Also make it height-adjustable (mine is not) if intended to roll outside. Also good to make it straddle your favorite trailer in case you have to unload machine tools or other forms of heaviness.
I'm sure there's more but that's all still stored in my flash drive