I keep individual kits for different types of home repair / projects with tool overlap as required. If I know I'm doing a specific type of project, I grab that kit along with any other common tools that aren't project specific like a drill.
One kit for painting / minor drywall repair is in a rubbermaid tub. 4'-8' Extension handle, long reach roller frame, and Sherwin Williams sample box are stored separate.
Electrical kit consists of one toolbox that has tools, wirenuts, pullstring, fishtape, misc. screws, etc. and a small rubbermaid tub that has wire, box / conduit fittings, etc. along with low voltage tools.
Tile kit is a toolbox and has various tools and specialty bits / blades for angle grinder, Dremel.
Plumbing kit is tools and misc related parts / supplies that get leftover from a job.
Kit in the house is a couple of pairs of Channellocks, regular pliers, utility knife, flashlight, 16' tape, adjustable wrench, 10 in 1 screwdriver, Bosch pocket driver and bits, 53 piece Craftsman socket set, etc. Saves a lot of trips to the garage for a simple task like tightening a cabinet pull.
Everything else is in the garage and gets put away as a project is completed. If I can't find something, I only have myself to blame 99% of the time.
All but one of my power tools came with cases. I try to keep as many related accessories for the tool in the case or as close to the case as possible. That includes bits, blades, grinding wheels, etc. Eliminates a lot of running and carrying an armload of tools for small projects.