it appears that most lift manufacturers want to see at least 4" of 3,000 lb concrete under their lifts.
I believe in an extra margin of safety and am wondering whether increasing the thickness of the slab is more effective in gaining strength than adding cement to the mixture ( to get stronger concrete )
Most of the finishing advice I've received personally and seen on this site recommends 4000 psi, so you should be set there. I also think you are well advised to go a little thicker - and watch closely! I specified 5" on my slab and was shocked to find it was being poured at 3.5". Fortunately, we were able to fix that during the pour. (My issue was due to challenges around the foam insulation installation and the fact that the floors were being poured to marks on the wall vs. an actual thickness.) I'm told that a good finisher should be able to get within 1/4" of spec, but how many people go back and confirm this in a residential setting? (Until its too late.)
You can
gradually taper the slab to be thicker around the posts, but you want to avoid any sharp thickness changes. Sharp thickness changes, along with some other advice above, can differential stresses in the slab - leading to major cracking. You should avoid changes in rebar/reinforcing across the slab, mixing different concretes, and sharp thickness changes unless the different sections are isolated by a full expansion joint. Adding in foundations or piles under the lift leg would also require the resulting "pads" to be isolated with an expansion joint. (Otherwise the general pad could settle around those piles and cause cracking.) Piles would also cause tipping concern for a 2 post lift.
If you want to go all out where your lift will be, you can section off the slab with an expansion joint, go all-out in the lift section, and go normal in the other area.
Putting down a nice flat (or gradually tapered) slab is going to be the strongest and lower maintenance option. Adding reinforcing will give you insurance against unwanted/unplanned cracking and may also allow you to space your saw cut joints further away from each other.
It's natural to think that thicker/stronger "foundations" or "pads" under lift posts are better. In reality, it gains nothing. (Unless its in a retrofit application.) It's possible to "key" pads in to the larger slab for the bending (in the slab) strength that the two post lift needs, but you then have cuts in the slab where fluids can easily infiltrate, etc.
In a very basic sense, there are two types of forces your slab will see from the two post lift: The gravitational force from the weight of the lift and vehicle and then the bending force in the slab created by off-centered loads on the lift.
The vertical bearing force is minimal due to the size of the metal pads on the lift. Depending on the size of those pads, the weight of the lift
could create less stress on the slab than the car just sitting there on the slab by itself. It all depends on the contact patch area of your tires and the surface area of the lift plates. Either way - the bearing pressure of your lift will be a few 10's of psi. Since your slab concrete is several 1000's of psi in compression strength, your slab won't even know the lift is there. (assuming the load is perfectly balanced) This is why you don't need foundations or pads
and why you won't find lift installation instructions calling for them.
If you look at a cross section of your slab with a lift post sticking out of it, you'll see the shape of an inverted "T." That shape resists bending at the base of the lift and counteracts any tipping forces caused by off-center loads. Having a nice contiguous slab makes a bigger and stronger "T."
That all being said, there are some folks who have used a very deep (and engineered) footing to counteract bending forces, but that's a really expensive compared to a nice, flat slab.