For a true "home run" system -- every outlet has a run back to the manifold ... including the ice maker and dishwasher. If you look at the flow needed -- 1/2 PEX is more than enough ... in fact 3/8 PEX can be used (and has been) for most fixtures. They all have limiters anyway.
The tubing should go directly from the manifold to the fixture -- fittings (if needed anyplace) should be expansion plastic that do not restrict flow.
Remember you are only feeding one fixture -- the manifold has a large feed to it. You can buy pre-insulated PEX for the hot water feeds.
I like the Viega manifolds. Funny thing ... the guys at the supply house said that some manufacturers are changing what they make because they can't get people to use the 3/8th pipe even though its the correct pipe for many applications .. so it's actually costing more in someplace. Some people also like the compression fitting at the manifolds -- in case things are changed .. no pipe damage.
I just re-ran the plumbing in my basement with the PEX and Viega ManaBloc system (in the past few weeks).
I actually installed two manifolds, in the spirit of GJ over-engineering.
From the top of my indirect water heater tank, I split the output. Half directly feeds the hot on one smaller manifold, which now supplies my washing machines, dishwasher and kitchen sink. And half goes through a Watts 70a mixing valve and sends 130F water to the other larger manifold that supplies showers and bathroom sinks.
The cold side of the smaller manifold supplies my outside hose bibbs, so that I can more easily isolate those and blow them out with air for the winter.
I used a mix of 1/2" and 3/8" pipe. 3/8" was easy to get online, but I can't find it locally. However, the ManaBloc will accept either, if you have the right fittings. I ran 3/8" to the bathroom sinks, laundries and toilets, simply because it's more flexible. I used 1/2" for the showers and outdoor spigots.
What sold the ManaBloc system for me was the easy shutoff on every line, and the fact that the valve cores can be replaced if you have issues over time.