If I were building the shop now, using them for a loft floor would have been a good idea, but it would be difficult now. The R30 guesstimate is from companies that sell them that advertise anywhere from R28 to R32. I'm in a mild climate, so R30 is plenty, as opposed to the R0 I have now. New houses being built around here are only R30 in the attic, R13 in the walls. I'm going to be R19 in the walls. As for the ceiling height, the ceilings are 12' 4-1/2", so no issue at all. I built them tall to allow for a lift, but I'm too old for a lift now, so that's not going to happen.
As for cost- I'm having a hard time finding cheap insulation. I hate doing drywall, as once it's up (the easy part) you have to tape, mud, sand, and paint. I'd only use drywall if I hired someone to do it. Same with blown in insulation. One of the logistical problems is that the shop is FULL of heavy stuff. I'm going to have to move stuff out of one area, finish the ceiling, then move the stuff back. A hired drywall guy isn't going to want to come back 4 or more times to do it in stages. Sure, the cooler panels won't look quite as nice, but I don't really care. They're white, and that's all I care about. My original plan was to insulate then cover it with metal roofing, but that stuff has gotten pricey. It's around a buck a square foot, plus insulation is also that much, so you're double the cost of the cooler panels.
I think locating the holes will be easy. Measure the spacing of the joists, and mark and drill from the back side (top) of the cooler panel. Then it doesn't matter if you wander a little drilling through. The surface that goes up against the joist will be in the right spot. 6" screws should be plenty.
I'm not trying to make this place living-space comfortable. In the winter, it gets down to the mid 30's in there. 50 would be fine. Same in the summer- it rarely gets above 80 in the shop, which is tolerable, although it's humid. I plan to use a min-split for HVAC. I have a finished great room on the other end of the barn, and it's fairly comfortable year-round with only R19 in the walls and ceiling. A small mini easily keeps it comfortable, and there's a 22' ceiling in there.