Try to find the source of the problem. If the tire and/or tube leaks, your next course of action should depend on how that leak got started. If tubeless, check for a good bead seal and clan off any rust that might be preventing it. As already said, use seam sealer if appropriate. If using an inner tube, make sure there are no sharp edges in the inner wheel poking at the rubber.
And don't forget valve stems! If you have to replace one on a tubeless setup, make sure the metal around it isn't rusting away. And if it's an inner tube, check the hole for rust and make sure that valve stem is centered through the hole and stays there as the tube is inflated.