After following along for the past several days and telling myself I wasn't going to chime in, I thought I may as well throw my two cents in.
I can see the manufacturer following a certain "laboratory" condition when applying wheels and torqueing to specification. However, we don't live in a "laboratory" condition, we live in the real world where we have a multitude of variable to contend with.
As wheel studs age and get used from lug nuts being removed and reapplied, the plating on the studs and nuts wears off, and things start to rust... anti-seize works to combat this. I completely get where the engineers are coming from (WOW, can't believe I just said that but I have to bite my tongue as I paid good money for my son to become one

) as anti-seize introduces an unknown that they have not tested nor accounted for... and can very well increase stud strain by an unknown amount. This is a valid concern. The problem herein lies is that age, corrosion, and worn plating introduce just as many uncertain variables into the equation of stud strain... and seized lug nuts are a routine cause of such problems. Seized lug nuts are hands down more problematic than loose lug nuts. Anti-seize eliminates this concern and in my experience, the margin or safety factor for lug nut torque is more than adequate to compensate for any increase in strain due to the anti-seize as long as you're careful to avoid over-torqueing. Wheel lug nut torque spec's usually have a range, example would be on my Jeep it is 85-125 ft/lbs. where I will stay to the lower end of the range due to the use of anti-seize to avoid over torqueing. I torque my Jeep's wheel studs to 95 ft/lbs.
Personally, I've used anti-seize on the lug nuts of every vehicle I've owned for the past 30+ years now. I have never had an issue, never a seized lug nut nor a broken lug stud from over-torqueing. Many other fasteners that I use anti-seize on I will usually reduce the torque spec. by approx. 20%. I have continued doing this after a late night discussion with my long time mentor that I learned from over 30 years ago now and it has proven to work in both in my home shop on my personal vehicles, race cars, customer cars (when I ran my speed shop) and in my full-time job in the industrial maintenance field.
This debate comes up quite often here on garagejournal and is old as the Ford vs. Chevy vs. Dodge debate.