I have 4 in my bedrooms being feed from an LG 48K BTU mainline to distribution box (7/8 inch return and 3/8 feed).
Each cassette uses a rotary fan not a squirrel cage fan and has a built-in condensate pump.
Each unit is 12K for heating or cooling but I don't use the heat portion.
Respective of a wall unit or in duct unit, these cassettes do cool down just as fast as the other form factors.
Cost-wise, I think they are a couple of hundred dollars more than the wall units. The ceiling vent frame is a separate cost item.
Install was easier in my opinion but I did have to cut ceiling rafters to get the unit in and held it in place with unistruts and 12-inch heavy-duty angles.
I brought all of the equipment from SupplyHouse.
It was a cleaner look and can be installed more centrally was my thinking.