Space is a concern also. Conventional condensing units are quite large compared to mini-split condensers. Air handlers and ducting are large as well. How large is this space. How tall the ceilings? How much attic access? The mini-s are typically quite a bit higher efficiency. I recently spoke with the fellow who bought my MA home and the mini I installed there is 21 yrs old and running perfectly. Yes, they are a pitn to clean, but you can learn how to do it and it is a once every year or two job other than cleaning the filters. With the exception of being able to add high MERV rated air filtration I see no benefits to ducted system. I have a JDS ambient air filter box n my garage that handles filtration there. Personally, I’m done with ductwork and will only use mini-splits.