Yes, I am saying that if you take precautions, you can very well do it in a home garage. Thousands of people do it every day. But you want to take the usual precautions as far as a respirator, you really don't want bare arms, and things like that.
And not to bash on you, but I am going to assume that either you run a full blown business, or you are an armchair Quarterback.

I started painting cars when I was 13 years old. I took precautions. I never had fresh air respirators. I'll be 58 next month. My dad lived to the ripe old age of 95 working with lead and paint.
I also have a young cousin that has contracted isocyanate poisoning, and I see what happens to him when he just gets around fresh paint.
A person can be safe without going totally overboard and spending thousands of dollars because they want to do something in the confines of their garage.