If you have access to paint guns and an air compressor, I would suggest using a polyester high build primer like Evercoat Featherfill G2 or PCL Polyprimer. If you have seams between different pieces of MDF, I would brush polyester resin (catalyzed hot) on the seams and joints, then wipe off the excess with a paper towel. No need to apply resin to the whole thing! Make sure to wipe off the excess. I wouldn't apply any fillers until after the first coat of primer. (I've primed and painted a lot of MDF.) The first coat of primer will be absorbed like a sponge on the cut ends and will be rough. Just sand (80 or 150 grit) and re-prime. Sand with 220 and 320/400 and it will be ready for darker colored automotive paint. Lighter colors and silvers will require a coat of sealer and/or sanding to 600 grit (or maybe even 800 grit). Good luck!