Yep, PEX all the way. When I did the addition on my house, remodeling the kitchen, adding a bathroom and shop, I redid that entire corner of the house into PEX, using a manifold and homeruns. It really was slick. A bit of investment in the tools but not too much, and learn a few lessons along the way, but really the best choice out there right now for supply lines. A few points, echoing what's already been said:
1) I found menards to be the cheapest big box store around for hardware, but even cheaper yet was supplyhouse.com, if you can figure out generally what you need and pre-order from them, then rely on the big box stores for odds and ends only, it will save you in the long run. I also got my manifold from these guys.
2) Don't use the plastic fittings. Use the brass only. If for some reason there's an overcrimping situation or possibly too much strain put on the connection point, you could spring a crack in the plastic fittings or barbs that won't get noticed till later on.
3) I use the SS cinch rings and they work well, but are pretty difficult to remove if you need to, but have heard a lot of good things about the uponor. Copper compression rings are good too. Pick one style at the get-go, then you are committed.
4) Home runs help but consider upsizing if you think your appliance really will gobble up lots of water, as the thicker wall means a smaller ID for a given size. For bathrooms fixtures such as shower or bathrub I really would go up to 3/4" minimum.
5) PEX needs to be secured every couple feet into place otherwise it can start to develop its own memory and try to move itself, especially as fixtures are open and closed. I have seen a number of the clamps that I used to secure it to joists simply fail over time. I used the plastic clamps w/ single mounting point, and I would not recommend using those, they'll snap eventually & let the tube loose to dangle. The Tube Talons is what they're called, I'd avoid them:
https://www.supplyhouse.com/Bluefin-PXTT050-Tube-Talon-for-1-2-PEX-Tubing-Bag-of-100
You should use a two-mount style to relieve the stress on the clamp, such as this one out of the plastic conduit aisle at lowe's:
https://www.lowes.com/pd/CARLON-25-Pack-1-2-in-PVC-Clamps/1100345
Good luck!