Chemistry must be maintained.
The German standard for oxygen diffusion is DIN4726 but even this approved barrier standard requires an annual oxygen diffusion test.
I looked at a home builder's own "DIY radiant" job yesterday. While building his own house the builder ran down to the nearest Big Box store to buy his PEX. He neglected to buy the oxygen barrier PEX and also go stuck on the heat source So the 2500 sq.ft basement is cold, -13°F this morning in Eden Prairie, MN, and I was called in to sort it out.
First. Oxygen is not the enemy; ferrous metal are. It is when the iron in the commonly used hydronic components oxidize from the oxygen naturally occurring in water that the problem arises. Once depleted, as a result of reacting with the ferrous metal--pump housings, expansion tank, etc.--a old style, all-metal system would normally work fine.
However, when you have a regular supply of oxygen migrating through the non-barrier PEX, the result can fill the system components up and even block flow through HX or the close spaces of valves. The higher the operating temperature, the higher the oxygen diffusion rate. Many radiant slab applications and snow melting system will suffer a very low diffusion rate. To the point that heat exchangers and even non-ferrous components are optional. In these low temperature applications the proper dose of inhibitor, as d suggests, may be all you need. But, you must maintain any heat transfer fluid for long term reliable operation, just as you do in your vehicles.
Generally, total system operating temperatures below 104°F will be safe, something we learned the hard way back in the 90's when we used non-barrier polybutylene for all of our radiant work. This excludes the use of mixed temperature systems e.g. cast iron boilers, outdoor boilers and mixing arrangements that allow any portion of the PEX to go above body temperature.
The answer is; separate the source of oxygen, typically with a plate heat exchanger or to design the system with non-ferrous metal components e.g. SS pumps and potable water expansion tanks.
This is done regularly on commercial applications where the extra 10 cents per lineal foot could add thousands to the PEX installation.
All hydronics systems should be flushed, cleaned, flushed again and treated with an appropriate corrosion inhibitor. Know what, how and when is the trick.
No disrespect to d.