From the owens corning chart, you'll get 17% better insulation with the R21 product that is intended for 2x6 walls.
http://www2.owenscorning.com/litera...ul Compressed R-Value Chart Tech Bulletin.pdf
In 2012 when I built a new home, I had 2 inches of closed cell foam sprayed into the 2x6 walls first, then applied R13 fiberglass in the remaining space for a total of R26. The spray foam in not cheap though. R60 blow-in fiberglass was placed in the ceilings.
The basement walls have R10 foam sheets, plus R13 batts in the 2x4 interior studs, for R23.
I have a 36x50 shop with about 70' linear feet of wall with a stepped foundation. I first applied R10 foam sheets to the interior foundation walls, extended 4' below floor level, as required by code, then built 70' of 2x4 interior walls (12' tall), that left about a 14" thick space to fill with fiberglass batts. The remaining walls have ordinary R19 batts. The entire floor also has R10 foam insulation under the 6" concrete floor.
With the 3000 square foot ranch (with basement) and the 1800 square foot shop, my highest natural gas heating bill was about $100 per month (subtracting $20 per month that the hot water heater uses). The shop is heated full time to 68 degrees.
Both home and shop are air conditioned. The highest electric bill for cooling both buildings is only about $70 per month, usually in July or August. I figure that, based on the difference between my lowest bill in the late spring or early fall and the highest in the summer. In the summer, I'm also running a 3/4 hp irrigation booster pump, about 7 hours per day.
I may not live long enough to get any return on the investment, but the building both perform well.