This is a good question...... I'm not completely sure of the answer, however, here is my logic on it....
The water needs to spend sufficient time in the tubes in the slab to transfer the heat to the slab. If your return water temperature is coming back X degrees higher than the slab temp, then the water is moving too fast. i.e. slow the pump down.
It will also make a different on if you are warming a cold soaked slab versus maintaining a slab. If your slab is 32 degrees or colder and you are trying to warm it to 65 degrees, the water will pretty much dump all of it's heat by the time it gets back to the manifold.... Probably use a faster speed.
Once the slab is warmed up, you can probably slow the pump down as your BTU requirement is lower to just maintain. Long term, you would probably see some small energy savings by running a little slower.....
Others can chime in with more info..... I've only had my floor heat installed for one winter, so I'm learning too....