Not an expert but here's my .02:
You don't specify your location. Are you worried only about cooling, or will winter heating also be a factor?
Insulation is (in my mind) the biggest step in keeping the garage cool, but you need to keep the attic above the insulation from keeping the hot air trapped. Passive roof vents or gable vents are exit avenues for the attic air. You need good soffit vents for air intake. If you've got good soffit vents for intake (or can add more) then a power ventilator might improve the air flow over static vents. Some experts say the powered systems pull too much air from the living spaces through cracks/leaks but that shouldn't be too bad for over the garage. If installed with the gable vent I'd put it as an exaust blower configuration drawing air ftrom the soffit vents and exiting through the gable vent.
I installed a COSTCO solar powered vent in the attic above my house last fall. It simply rplaced one of the existing passive roof vents. The instructions said to block off all the other passive vents so the solar fan would **** outside air only through the soffit vents and exhaust through the single fan vent. It's temperature controlled in the summer and humidity controlled in the winter. Had it for over a year so far without any problems.
For my garage project, I'm just going with passive ventilation. I'm adding 2 more roof vents to the 2 existing over my 3-1/2 car garage and doubling the soffit vents to insure adequate airflow both summer and winter. Once that's done and my lighing, electrical wiring and roof heater are installed' I'll blow-in insulation in both the ceiling and walls to better control the environment.
Putting in a whole house fan just for the garage might be a bit of overkill, but should work for cooling in the hot season, not sure what it'd do for you if you have cold winters...
Paul