The roll ups don't cause problems with ceiling lights or other ceiling mounted stuff (like hoists, etc) when open.
But They don't seal against air infiltration as well as the overhead types.
On a related note, there are brush seals available for the roll ups. And, as I'm planning to install one soon, I've been looking. Can't find any that are reasonably priced and with long enough brushes to work well. At least the cheaper ones don't look long enough to work on the corrugated metal.
Anyone have a good source for these???