Your best bet is to try out a handle from each reputable brand and see how it feels in your hand. Make sure to try out the same size (I did Phillips 2 or P2 because that is probably the most common screw there is out there) for each, because larger tips have larger handles for many brands. You may just like the feel of a larger handle if you don't compare identical sizes to each other.
I did this about a year ago when I decided to drop the horrible craftsman acetate handle screwdrivers I was using. I had gone through 3 P2 screwdrivers in a week and was sick of warrantying them for new ones. I tried out
Snap On hard and soft instinct grips
Craftsman Pro/SK/Armstrong
Masterforce Acetate handles (made by Pratt Read, not Western Forge, so slightly different handles and stronger tips than the craftsman acetate handles)
Felo Ergonic
Wera Kraftform
Wiha Soft Finish
For the Snap On, I liked them, but didn't like the price and found a brand I like more later
The CMAN Pro in store and didn't like them as they were too bulky. Comfortable and sturdy, but bulky for one handed use I felt like. SK and Armstrong are the exact same, just different colors and names on it.
Masterforce Acetate handles were nice. They are a different design from Craftsman regular acetate handles, and I like it better, plus the precision screwdriver set I had from them had held up incredibly well to several years of use. Again, passed because I found another one I liked better.
Felo Ergonic. I LOVED them. Except for two spots in the handle. It's a nice squishy handle, but the squishy material is contained in two separate areas that are separated by a rather hard plastic divider. So all the screwdriver handle was squishy except for two hard lines the entire length of the handle. Ruined the screwdrivers for me.
Wera- This was a front runner for me when I ordered a few screwdrivers. The look of the handled looked like it would be incredibly comfortable. Nope. Hate the way it fits my hand. The middle hard plastic ring hits the middle of my palm. I feel like they were made for people with smaller hands than me.
Wiha Soft finish. I picked up this one and fell in love with it. Simple, yet incredibly ergonomic. Fits the hand, fingers, and palms very well. Great grip on it for torque. Just a wonderful screwdriver. Had it for about a year and the tip doesn't even have a scratch on it. Remember, I used to go through craftsman acetate handle screwdrivers at the rate of one a week or so. Huge improvement in life, comfort, and value.
Just go to a store and hold some in your hand. You'll get a feel for what you like and what you don't.
