I'm a bit of an arachniphobe, so even though I love the role of spiders in nature, they irrationally give me the willies.
My old garage in my first rental here in St Louis was infested with brown recluses. Dozens and dozens of the in the garage every year. The landlord took the doors off the garage to ease maintenance and that didn't help. I'd find them in the basement or bathtub, too. Yuck.
I had a very strange bit one time on my thigh -- a hard, ulcerating red welt that took a month or more to go away. Quite possible a brown recluse bite.
My house now has a detached brick garage that isn't sealed tight. Keeping spiders and insects of all types out is an ongoing process of "control". I keep the corners open and clean. I bug-bomb twice a season. I regularly spray corners, windows, door openings, rafters, etc with Ortho Home Defense Max (or the Raid equivalent from Costco sometimes) to put some sort of barrier in place.
I don't have a problem, but the place is never quite sterile either.
Don