no problem
The Main Wind Force Resisting System (MWFRS) of a building is the framing that resists the external forces applied to the building and supports the internal loads determined by the service of the building.
The external forces are :
1. Wind
2. Snow (blanket and/or drift)
3. Earthquake
4. Retained earth
5. Rain ponding
The internal loads are most often :
1. Dead load DL (flooring, partitions and things that generally don't move)
2. Live load LL (people etc)
3. Service loads unique to that building
4. etc
The International Building Code stipulates minimum values for all of these loads. It's a book about, ohh, 2 inches thick and covers just about everything to do with buildings.
Where the building is determines most of the external forces. Snow loads in Alaska are a little higher than those in Alabama, while coastal wind speeds are higher than inland areas. The IBC defines each of the terms, and has maps showing snow loads, wind speeds etc etc and etc for the US. Wind acceleration due to ridges etc is also covered ... but I digress.
Once I know where a building is I can determine the forces that act upon the envelope of the building. Depending upon the Design Wind Speed a 2x4 stud may be fine, but when a snow drift against it is added to that wind load it may fail, so we can tighten up the spacing or make them bigger.
When we add a floor above the studs are now acting as columns to resist the vertical loads from the floor while still acting as a 'beam' to resist the wind and other horizontal loads. The IBC has pages covering all the different types of rooms that are commonly found and the respective minimum load to be applied to those floors.
A "storeroom" has a minimum live load of 125psf (ok while things that are stored don't often move the load is still called 'live') while a residential floor has a minimum LL of 40psf. A public floor space has a LL of 100, or 150 when it's in a fire egress corridor ... and etc.
Not knowing the geometry of the building in question here, but knowing that it has a floor above it's possible that the vertical load from that floor plus the horizontal loads on the wall may exceed what we call 'unity' for a 2x4 stud. In other words the ration of the sum of the applied bending and axial stresses divided by the maximum allowed for that grade timber is greater than one.
In other words it fails.
It's pretty rare for an external wall supporting a floor to have 2x4 studs.
HTH's