Related question- How do you move those things? I've found a few for sale, but didn't pull the trigger due to the problem of moving them. The only equipment I have is a cherry picker, but I've moved lathes and mills with it. The old drill presses look so top-heavy. Take it apart? Lay it down somehow?
I don't know if it's the right way but I've moved my 18" Clausing (around 400 lb.) a couple of times now with no resulting damage. They are top heavy so the first thing to go is the cast iron beltguard. I have moved it myself around the garage and homestead either by "walking" it on the base or a hand truck (think refrigerator dolly). Make sure you have help and be very careful as it can go past the balance point and start tipping over in an instant. I have moved it around on a furniture dolly once or twice but I found the hand truck to be easier.
For long distance moves, it depends. If the truck is full you can stand it in a corner, packed in with other items so it just can't move. When I moved it from NY to GA there was nothing in the truck body strong enough to tie it to and the trunk was basically empty so we laid it down. We actually built cribbing into the wooden truck floor to support the DP structure anywhere it needed it and hold it in place for the trip. For the move from GA to SC we used an open trailer, loose cribbing, and strapped everything down.
You could also take it apart. You would really only have to take off the head but you would definitely need a hoist or cherry picker to accomplish that. If you had a vehicle with enough and strong enough tie downs, the best way would be upright and tied down tight so it can't tip.
Hope that answers some of your question. Perhaps the above isn't best practices but it has worked for me.
Lou Manglass