I have a friend doing 12v emergency/mood lighting in his house. It's a new build, so he was able to run all the wires how he wanted, a home fabbed panel (3d printer/laser/snap in terminal blocks) and some sort of standard plugs at the ends (maybe just USB or similar, to be available long term).
For now he's doing a boat battery and a single solar panel, but the wiring will support a larger array.
He also built a Ford Transit into a camper, and wired that, so part of his plan is to be able to test parts and products and develop accessories for other van people, in the house at a real work bench.
When I asked about doing more "real" lighting and appliances, he said there were too many road blocks, and the 12v stuff is just for fun, and the basic functionality of the house needed to be traditional.
So, if the goal is to play 12v, and have Something Different, go for it. If the goal is to have a well lit shop to build things in, go traditional and get on with it.