Whether the units will "do it" or not depends on the load.
Window AC units "window shakers" are not very efficient. You can get a modulating air-to-air mini-split that modulates output and use one outside compressor with multiple inside heads or air handlers.
If you have to use a mini-split you want it properly sized to the load as unit that is too small will not keep up and over-sized AC units will not properly de-humidify the space.
Naturally, you the main criteria for sizing any heating or cooling appliance is your local climate.