fourstringriot
It's hard to say much about your proposal without knowing the size of the office, how often it will be occupies, how much insulation you have, your electric rates, etc.
Just to toss out some information for comparison, I have a rural home in SW Indiana that is a 36' x 64' footprint with about half the first floor as living area and the other half as garage. It's a 12/12 pitch roof build with attic trusses so I have a finished area upstairs 18' wide x 64' long (divided into three rooms). I'm all electric with one heat pump upstairs and one downstairs (Having two separate systems solved some ductwork issues and provides a backup system in case one fails.) The systems are about 10 years old and rated at 13 SEER.
I spend most of the summers there, but turn the AC to about 80 when I'm gone. I don't spend much time there in the winter, but leave the heat at about 62 degrees when I'm gone. Over the past three years my electric bills have average just over $100 per month (I had a couple of months two winters ago when one heat pump was operating on auxiliary resistance heat full time because of a short in a wire.) My low bill during the period was $65+ in a month when neither the heat or air conditioning was running much (if at all). This $65 was the $30 per month fixed charge plus the cost of a water heater, security lights, appliances, etc. Based on this, I'm estimating that I'm spending less than $500 per year to heat and cool the house.
I mention this figure because a lot of folks like to tell me that I could save big money if I had the latest super efficient system. (one fellow who tried to sell me a geothermal system said that I could save $2000 per year with his system.)
I'm sure that the high end Mitsubishi system is great. I imagine that the installed quote includes a lot of profit, but is probably not far out of line with competition. However, there are a lot of lesser systems (such as PTHP units like you see in a hotel) that are starting to use inverter technology and the installation costs COULD be minimal. You might also want to consider if your overall cost would be lower if you spent more on insulation and less on HVAC equipment.